Estimate your potential success rate with Intrauterine Insemination (IUI) based on key factors.
Unexplained Infertility
Mild Male Factor
Ovulatory Dysfunction
Mild Endometriosis
Your estimated success rate will appear here.
Understanding Your IUI Success Rate
Intrauterine Insemination (IUI) is a common and relatively straightforward fertility treatment that involves placing specially prepared sperm directly into the uterus around the time of ovulation. While it offers a higher chance of conception than intercourse for many couples, the success rate can vary significantly based on several individual factors. This calculator aims to provide a personalized estimate based on the most influential variables.
Factors Influencing IUI Success:
Maternal Age: This is perhaps the most significant factor. Egg quality and quantity naturally decline with age, directly impacting the chances of a successful pregnancy. Younger women generally have higher success rates.
Number of Cycles Attempted: For some conditions, such as unexplained infertility, the cumulative success rate increases with each subsequent IUI cycle performed. However, there are diminishing returns, and a point where other treatments may be considered.
Primary Fertility Diagnosis: The underlying cause of infertility plays a crucial role. IUI is often most effective for conditions like mild male factor infertility, ovulatory dysfunction (like PCOS), or mild endometriosis. Its effectiveness for severe male factor or significant uterine scarring may be lower.
Ovarian Stimulation: In some IUI protocols, fertility medications are used to stimulate the ovaries to produce more eggs. The number of mature follicles resulting from stimulation can influence the chance of conception, as having more eggs increases the odds of fertilization.
Number of Mature Follicles: During an ultrasound monitoring, the number and size of developing follicles (which contain eggs) are assessed. A higher number of mature follicles, typically considered those measuring 17mm or larger, can correlate with a higher chance of pregnancy.
Endometrial Thickness: The endometrium is the lining of the uterus where a fertilized egg implants. A sufficient thickness, generally considered 8mm or more, is crucial for successful implantation. Studies suggest a thickness between 8-12mm is often optimal.
How the Calculator Works (Simplified Model):
This calculator uses a simplified, probabilistic model. It assigns different weights and influences to each input factor. The core idea is to adjust a baseline success rate (which might be around 10-20% for an average case) based on how each input deviates from typical favorable conditions. For example:
Age: Decreasing the success rate significantly as age increases beyond the mid-30s.
Diagnosis: Assigning higher baseline success for conditions like mild male factor and lower for more complex issues.
Follicles/Thickness: Increasing the rate with more mature follicles and optimal endometrial thickness.
Stimulations: Modestly increasing the rate with the number of stimulations for certain diagnoses, reflecting cumulative chances.
Disclaimer: This calculator provides an *estimated* success rate for informational purposes only. It is not a substitute for professional medical advice. Actual IUI success rates depend on a multitude of factors, including the specific clinic's protocols, sperm quality parameters (motility, count), and individual biological responses. Always consult with your fertility specialist for accurate prognostication and treatment planning.
Example Calculation:
Let's consider a 32-year-old woman with unexplained infertility, who has attempted 1 cycle without intervention. Her doctor recommends stimulation, resulting in 2 mature follicles (>17mm) and an endometrial lining of 11mm. She has had 1 stimulation cycle.
Maternal Age: 32 (Favorable)
Cycles Without Intervention: 1 (Neutral)
Fertility Diagnosis: Unexplained Infertility (Moderate success potential for IUI)
Stimulations: 1 (Slightly positive)
Mature Follicles: 2 (Positive)
Endometrial Thickness: 11mm (Optimal)
Based on these factors, the calculator might estimate a success rate in the range of 15-25% per cycle, reflecting the good follicular development and endometrial lining despite unexplained infertility.
function calculateIUISuccessRate() {
var age = parseFloat(document.getElementById("age").value);
var cyclesWithoutIntervention = parseFloat(document.getElementById("cyclesWithoutIntervention").value);
var fertilityDiagnosis = document.getElementById("fertilityDiagnosis").value;
var stimulations = parseFloat(document.getElementById("stimulations").value);
var follicles = parseFloat(document.getElementById("follicles").value);
var endometrialThickness = parseFloat(document.getElementById("endometrialThickness").value);
var resultElement = document.getElementById("result");
resultElement.style.backgroundColor = "#6c757d"; // Default to gray if invalid
resultElement.style.color = "#ffffff";
// — Input Validation —
if (isNaN(age) || age 55) {
resultElement.textContent = "Please enter a valid age.";
return;
}
if (isNaN(cyclesWithoutIntervention) || cyclesWithoutIntervention < 0) {
resultElement.textContent = "Please enter a valid number for previous cycles.";
return;
}
if (isNaN(stimulations) || stimulations < 0) {
resultElement.textContent = "Please enter a valid number for stimulations.";
return;
}
if (isNaN(follicles) || follicles < 0) {
resultElement.textContent = "Please enter a valid number for mature follicles.";
return;
}
if (isNaN(endometrialThickness) || endometrialThickness <= 0) {
resultElement.textContent = "Please enter a valid endometrial thickness.";
return;
}
// — Base Success Rate (Conceptual) —
// This is a highly simplified model. Real-world probabilities are complex.
// A general average success rate for IUI might be considered ~10-20% per cycle.
// We'll use a baseline and adjust it.
var baseRate = 15.0; // Percentage
// — Adjustments based on factors —
// Age Adjustment: Significant impact
var ageFactor = 1.0;
if (age = 30 && age = 35 && age = 40) {
ageFactor = 0.4; // Significantly lower rate
}
// Diagnosis Adjustment
var diagnosisFactor = 1.0;
switch (fertilityDiagnosis) {
case "unexplained":
diagnosisFactor = 0.9; // Moderate
break;
case "mildmale":
diagnosisFactor = 1.1; // Good for IUI
break;
case "ovulatory":
diagnosisFactor = 1.05; // Good for IUI
break;
case "mildendo":
diagnosisFactor = 0.95; // Mildly affected
break;
default:
diagnosisFactor = 1.0;
}
// Number of Stimulations (cumulative effect, slightly positive)
// Only adds a small benefit, especially for younger patients or specific diagnoses.
var stimulationsFactor = 1.0 + (Math.min(stimulations, 3) * 0.02); // Max 6% boost from stimulations
// Follicles Adjustment (More is generally better, up to a point)
var folliclesFactor = 1.0;
if (follicles === 0) {
folliclesFactor = 0.5; // Significantly lower if no mature follicles
} else if (follicles === 1) {
folliclesFactor = 0.9;
} else if (follicles === 2) {
folliclesFactor = 1.1;
} else if (follicles >= 3) {
folliclesFactor = 1.2; // More follicles potentially increase odds
}
// Endometrial Thickness Adjustment (Crucial for implantation)
var endometriumFactor = 1.0;
if (endometrialThickness = 7 && endometrialThickness = 9 && endometrialThickness 12mm can sometimes be associated with lower success, but less common
endometriumFactor = 1.05;
}
// Previous Cycles (can indicate resilience or lack of success)
// This is tricky. For unexplained, more cycles *might* mean higher cumulative chance.
// For others, it might mean the treatment isn't working. We'll add a small boost for higher cycles IF diagnosis isn't severe.
var cyclesFactor = 1.0;
if (cyclesWithoutIntervention > 2 && (fertilityDiagnosis === "unexplained" || fertilityDiagnosis === "ovulatory")) {
cyclesFactor = 1.0 + (Math.min(cyclesWithoutIntervention, 4) * 0.015); // Small cumulative boost
} else if (cyclesWithoutIntervention > 0) {
// No significant boost or potentially negative if it implies repeated failure
}
// — Combine Factors —
var estimatedRate = baseRate * ageFactor * diagnosisFactor * stimulationsFactor * folliclesFactor * endometriumFactor * cyclesFactor;
// — Cap and Round —
estimatedRate = Math.max(5.0, Math.min(estimatedRate, 35.0)); // Clamp between 5% and 35%
estimatedRate = Math.round(estimatedRate * 10) / 10; // Round to one decimal place
resultElement.textContent = estimatedRate + "% Success Rate";
resultElement.style.backgroundColor = "var(–success-green)"; // Indicate successful calculation
}