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.propofol-calc-row input:focus { border-color: #004a99; }
.propofol-calc-btn-container { text-align: center; margin-top: 30px; }
.propofol-calc-btn { background-color: #004a99; color: #fff; border: none; padding: 15px 40px; font-size: 18px; font-weight: bold; border-radius: 8px; cursor: pointer; transition: background 0.3s; }
.propofol-calc-btn:hover { background-color: #003366; }
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.propofol-result-box h3 { margin-top: 0; color: #004a99; }
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.propofol-article h3 { color: #004a99; margin-top: 25px; }
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.propofol-article th { background-color: #f2f2f2; }
How to Calculate Propofol Infusion Rates
Propofol (Diprivan) is a short-acting intravenous anesthetic agent used for the induction and maintenance of general anesthesia, as well as sedation for mechanically ventilated adults in intensive care units (ICU). Accurate calculation of the drip rate is critical for patient safety, as Propofol has a narrow therapeutic window and rapid onset of action.
The standard concentration of Propofol is 1% (10 mg/mL). In some specialized settings, a 2% (20 mg/mL) concentration may be used to limit fluid intake. Dosing is typically calculated in micrograms per kilogram per minute (mcg/kg/min).
The Propofol Drip Formula
To convert a weight-based dose (mcg/kg/min) into a volumetric flow rate (mL/hr), the following formula is applied:
Flow Rate (mL/hr) = [Dose (mcg/kg/min) × Weight (kg) × 60 (min/hr)] / [Concentration (mg/mL) × 1000 (mcg/mg)]
Example Calculation
If a physician orders a Propofol infusion at 30 mcg/kg/min for a patient weighing 80 kg, using a standard 10 mg/mL concentration, the calculation would be:
- Step 1: Calculate total mcg per minute: 30 mcg/kg/min × 80 kg = 2,400 mcg/min.
- Step 2: Convert mcg to mg: 2,400 mcg / 1,000 = 2.4 mg/min.
- Step 3: Calculate mg per hour: 2.4 mg/min × 60 min = 144 mg/hr.
- Step 4: Convert to mL per hour: 144 mg/hr / 10 mg/mL = 14.4 mL/hr.
Common Propofol Dosing Ranges
| Indication |
Typical Dose Range |
| ICU Sedation |
5 – 50 mcg/kg/min |
| Monitored Anesthesia Care (MAC) |
25 – 75 mcg/kg/min |
| General Anesthesia Maintenance |
100 – 200 mcg/kg/min |
Disclaimer: This tool is for educational purposes only. Clinical decisions should be made by licensed medical professionals using validated institutional protocols and direct clinical assessment. Always double-check infusion pump settings manually.
function calculatePropofolDrip() {
var weight = parseFloat(document.getElementById("pWeight").value);
var dose = parseFloat(document.getElementById("pDose").value);
var concentration = parseFloat(document.getElementById("pConcentration").value);
var resultDiv = document.getElementById("propofolResult");
if (isNaN(weight) || weight <= 0 || isNaN(dose) || dose <= 0) {
alert("Please enter valid positive numbers for weight and dose.");
resultDiv.style.display = "none";
return;
}
// Formula: (mcg/kg/min * kg * 60 min/hr) / (1000 mcg/mg * concentration mg/mL)
var totalMcgPerMin = dose * weight;
var totalMgPerHour = (totalMcgPerMin * 60) / 1000;
var mlPerHour = totalMgPerHour / concentration;
// Display values
document.getElementById("resDoseText").innerText = dose;
document.getElementById("resWeightText").innerText = weight;
document.getElementById("resFlowRate").innerText = mlPerHour.toFixed(1);
document.getElementById("resTotalMg").innerText = totalMgPerHour.toFixed(1);
// Show result
resultDiv.style.display = "block";
resultDiv.scrollIntoView({ behavior: 'smooth', block: 'nearest' });
}