Amiodarone Infusion Rate Calculation

Amiodarone Infusion Rate Calculator

This calculator helps determine the correct infusion rate for Amiodarone, a medication used to treat certain types of serious irregular heartbeats (arrhythmias). It's crucial to use the correct infusion rate to ensure therapeutic effectiveness while minimizing the risk of adverse effects.

Understanding Amiodarone Infusion Rates

Amiodarone is often administered as a loading dose followed by a maintenance dose. This calculator focuses on the initial loading dose infusion rate. The calculation ensures that the prescribed dose per kilogram of body weight is delivered over the specified infusion period.

Formula:

Total Amiodarone needed (mg) = Patient Weight (kg) × Loading Dose (mg/kg)

Total Volume to infuse (mL) = Total Amiodarone needed (mg) / Amiodarone Concentration (mg/mL)

Infusion Rate (mL/hour) = Total Volume to infuse (mL) / Infusion Duration (hours)

Example:

If the patient weighs 70 kg, the desired loading dose is 5 mg/kg, the amiodarone concentration is 1.8 mg/mL, and the infusion duration is 1 hour:

  • Total Amiodarone needed = 70 kg × 5 mg/kg = 350 mg
  • Total Volume to infuse = 350 mg / 1.8 mg/mL ≈ 194.44 mL
  • Infusion Rate = 194.44 mL / 1 hour ≈ 194.44 mL/hour

Disclaimer: This calculator is for informational purposes only and should not replace professional medical judgment. Always consult with a qualified healthcare provider for any health concerns or before making any decisions related to your treatment.

function calculateAmiodaroneRate() { var drugConcentration = parseFloat(document.getElementById("drugConcentration").value); var patientWeightKg = parseFloat(document.getElementById("patientWeightKg").value); var loadingDoseMg = parseFloat(document.getElementById("loadingDoseMg").value); var infusionDurationHours = parseFloat(document.getElementById("infusionDurationHours").value); var resultDiv = document.getElementById("result"); resultDiv.innerHTML = ""; // Clear previous results if (isNaN(drugConcentration) || drugConcentration <= 0) { resultDiv.innerHTML = "Please enter a valid Amiodarone concentration (mg/mL)."; return; } if (isNaN(patientWeightKg) || patientWeightKg <= 0) { resultDiv.innerHTML = "Please enter a valid patient weight in kilograms."; return; } if (isNaN(loadingDoseMg) || loadingDoseMg <= 0) { resultDiv.innerHTML = "Please enter a valid loading dose (mg/kg)."; return; } if (isNaN(infusionDurationHours) || infusionDurationHours <= 0) { resultDiv.innerHTML = "Please enter a valid infusion duration in hours."; return; } var totalAmiodaroneMg = patientWeightKg * loadingDoseMg; var totalVolumeMl = totalAmiodaroneMg / drugConcentration; var infusionRateMlPerHour = totalVolumeMl / infusionDurationHours; resultDiv.innerHTML = "

Calculated Infusion Rate:

" + "Total Amiodarone Needed: " + totalAmiodaroneMg.toFixed(2) + " mg" + "Total Volume to Infuse: " + totalVolumeMl.toFixed(2) + " mL" + "Infusion Rate: " + infusionRateMlPerHour.toFixed(2) + " mL/hour"; }

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