How to Calculate Kidney Function

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eGFR Kidney Function Calculator

Estimate your Glomerular Filtration Rate using the 2021 CKD-EPI formula.

Male Female

How Kidney Function is Calculated

Kidney function is primarily measured using the Estimated Glomerular Filtration Rate (eGFR). This value represents how many milliliters of blood your kidneys filter per minute. Since it is difficult to measure directly, doctors use formulas based on markers in your blood, most commonly creatinine.

This calculator uses the CKD-EPI (2021) equation, which is currently the clinical standard. It provides an estimate based on your serum creatinine level, age, and biological sex, without requiring a race-based adjustment.

Understanding Your Results

A normal eGFR for adults is usually above 90 mL/min/1.73m². However, GFR naturally declines with age. Below is the standard classification for Chronic Kidney Disease (CKD) stages:

Stage eGFR Level Description
Stage 1 90 or higher Normal kidney function, but other signs of kidney damage may be present.
Stage 2 60 – 89 Mildly decreased kidney function.
Stage 3a 45 – 59 Mild to moderate decrease in kidney function.
Stage 3b 30 – 44 Moderate to severe decrease in kidney function.
Stage 4 15 – 29 Severely decreased kidney function.
Stage 5 Less than 15 Kidney failure (Requires dialysis or transplant).

Why Creatinine Matters

Creatinine is a waste product that comes from the normal wear and tear on muscles of the body. Healthy kidneys filter creatinine from the blood and pass it out of the body through urine. When the kidneys are not working properly, creatinine builds up in the blood. Therefore, a high serum creatinine level often indicates low kidney function.

Important Considerations

While the eGFR is a powerful tool, it may not be accurate for everyone. Factors that can skew the results include:

  • Extreme body size (severe obesity or malnutrition).
  • Pregnancy.
  • High muscle mass (athletes or bodybuilders).
  • Recent consumption of cooked meat.
  • Use of certain medications or supplements (like creatine).

Disclaimer: This calculator is for educational purposes only. Always consult with a healthcare professional to interpret your lab results and diagnose medical conditions.

function calculateKidneyFunction() { var scr = parseFloat(document.getElementById('k_creatinine').value); var age = parseFloat(document.getElementById('k_age').value); var gender = document.getElementById('k_gender').value; var resultBox = document.getElementById('k_result_box'); var resultDisplay = document.getElementById('k_result_display'); var statusDisplay = document.getElementById('k_status_display'); var interpretationDisplay = document.getElementById('k_interpretation'); if (isNaN(scr) || isNaN(age) || scr <= 0 || age <= 0) { alert("Please enter valid positive numbers for Creatinine and Age."); return; } // 2021 CKD-EPI Creatinine Equation // GFR = 142 * min(Scr/kappa, 1)^alpha * max(Scr/kappa, 1)^-1.200 * 0.9938^Age * [1.012 if Female] var kappa = (gender === 'female') ? 0.7 : 0.9; var alpha = (gender === 'female') ? -0.241 : -0.302; var genderMultiplier = (gender === 'female') ? 1.012 : 1.0; var ratio = scr / kappa; var minPart = Math.pow(Math.min(ratio, 1), alpha); var maxPart = Math.pow(Math.max(ratio, 1), -1.200); var agePart = Math.pow(0.9938, age); var egfr = 142 * minPart * maxPart * agePart * genderMultiplier; var finalGFR = Math.round(egfr); resultDisplay.innerHTML = finalGFR + " mL/min/1.73m²"; resultBox.style.display = "block"; var status = ""; var color = ""; var note = ""; if (finalGFR >= 90) { status = "Stage 1: Normal Kidney Function"; color = "#28a745"; note = "Your eGFR is in the normal range. Keep maintaining a healthy lifestyle."; } else if (finalGFR >= 60) { status = "Stage 2: Mildly Decreased Function"; color = "#8bc34a"; note = "This is a mild decrease. It may be normal for your age or indicate early stages of kidney issues if other symptoms exist."; } else if (finalGFR >= 45) { status = "Stage 3a: Mild to Moderate Decrease"; color = "#ffc107"; note = "This indicates a moderate reduction in kidney function. Consult a doctor for further evaluation."; } else if (finalGFR >= 30) { status = "Stage 3b: Moderate to Severe Decrease"; color = "#fd7e14"; note = "Significant reduction in kidney function. Medical consultation is strongly advised."; } else if (finalGFR >= 15) { status = "Stage 4: Severely Decreased Function"; color = "#dc3545"; note = "Severe kidney damage. You should be under the care of a nephrologist."; } else { status = "Stage 5: Kidney Failure"; color = "#721c24"; note = "Kidney failure is present. Immediate medical intervention is required."; } statusDisplay.innerHTML = status; statusDisplay.style.color = color; interpretationDisplay.innerHTML = note; resultBox.scrollIntoView({ behavior: 'smooth', block: 'nearest' }); }

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